The MUCIN BIOLOGY GROUPS are led by Gunnar C. Hansson, Malin E.V. Johansson, Thaher Pelaseyed, and George Birchenough and are among the major research groups of the Department of Medical Biochemistry at the Sahlgrenska Academy, the Medical Faculty of University of Gothenburg.
Mucin gels were rapidly colonized by heterogeneous bacterial populations, especially members of the Bacteroides fragilis group, enterobacteria, and clostridia. Intestinal bacterial populations growing on mucin surfaces were shown to be phylogenetically and metabolically distinct from their planktonic counterparts.
av M PiHl · Citerat av 4 — formation or eradicate biofilms from peritoneal dialysis catheters, thus reducing the number aerobes as a group are frequently encountered in peritonitis, for example the above 2006). Host carbohydrates, such as, mucins and cell surface Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259; and. 3. Pharmaceutical groups were removed and prepared for histology and mucus. quantitation as mucin transcripts takes ⬃24 h, whereas the presence.
It is present in saliva and bile and in salivary glands, in the skin, connective, tissues, tendon, and 2001-12-01 2011-05-03 Mucin polymers coat all the wet surfaces in the human body, providing a selective barrier that allows nutrients and information in while keeping pathogens out. Our laboratory works in three areas of mucus biology 2021-01-19 Gastrointestinal mucins produced by goblet cells comprise the main structural components of the mucus layer. Mucins play a critical role in the maintenance of mucosal homeostasis and are responsible for the differential effector and regulatory responses against a plethora of microorganisms, including commensals and pathogens. Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Protein family/group databases. MEROPS i: I08.953: Names National Institutes of Health The European Molecular Biology Laboratory State Secretariat for Education, 2018-08-06 Math Biology Seminar. Mucin Exocytosis.
membrane mucins in mucosal innate immunity. Membrane mucins cover the brush border membrane of enterocytes throughout the intestine, but their function remains undefined. Our aim is to elucidate the function of membrane mucins in intestinal barriers and to determine how we can harness the function of membrane mucins in order to combat diseases such as Inflammatory bowel disease (IBD) and endemic intestinal infections.
2011-05-03 · May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers.
Mucins are forming the gel-like properties of mucus. The major mucin of the gastrointestinal tract is called MUC2 and is produced by the intestinal goblet cells. There are two main groups of mucins; the classical gel-forming polymeric mucins (MUC2, MUC5AC, MUC5B, and MUC6) and a more heterogeneous group of monomeric transmembrane mucins (MUC1, MUC3, MUC4, MUC12, MUC13, MUC15, MUC16, MUC17, MUC20, and MUC21). One research group attempting to identify the specifics regarding mucins is the Mucin Biology Group at the University of Gothenburg in Sweden.
As noted above, the defining feature of mucin O-linked glycosylation compared to other types of glycosylation is the initial addition of GalNAc to Ser/Thr residues of protein substrates. 37 One useful group of metabolic inhibitors of mucin O-linked glycosylation utilizes GalNAc analogs as decoy primers that suppress elaboration of O-linked glycans. 50,51 These unnatural sugars exploit two
The intestinal mucus proteome is ∼ 50 proteins with a few that are very abundant. The major component is the MUC2 mucin, the function of which has been determined in recent years.
Professor Gunnar C. Hansson, MD, PhD. Mucin Biology Groups, Dept. Medical Biochemistry, University of Gothenburg.
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Mucins are extracellular large highly glycosylated molecules having mucin domains. Usually one also demands that there is more than 50% of the mass that is due to glycans. Mucin domains (with glycans) or PTS domains (protein core only) are found also in other extracellular proteins, but are dominating in molecules that are usually called mucins.
There are two main groups of mucins; the classical gel-forming polymeric mucins (MUC2, MUC5AC, MUC5B, and MUC6) and a more heterogeneous group of monomeric transmembrane mucins (MUC1, MUC3, MUC4, MUC12, MUC13, MUC15, MUC16, MUC17, MUC20, and MUC21). One research group attempting to identify the specifics regarding mucins is the Mucin Biology Group at the University of Gothenburg in Sweden. There are currently more than 20 human mucin genes that have been identified. The genes encoding mucin proteins are generally designated MUC (MUC1-MUC20) and have homologs in many species other than humans.
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2020-06-09 · The main mucin proteins secreted by goblet cells in the respiratory tract are called MUC5AC and MUC5B. In the respiratory tract, they more often secrete another mucin protein, MUC2. Goblet cells produce and secrete mucins which are a component of mucus. Mucus lines the epithelium of respiratory and gastrointestinal tissues. Mucus
However, the lack of chemical tools to study mucin-type O-linked glycosylation has hindered our molecular understanding of O-linked glycans in many biological contexts. As noted above, the defining feature of mucin O-linked glycosylation compared to other types of glycosylation is the initial addition of GalNAc to Ser/Thr residues of protein substrates. 37 One useful group of metabolic inhibitors of mucin O-linked glycosylation utilizes GalNAc analogs as decoy primers that suppress elaboration of O-linked glycans.
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One research group attempting to identify the specifics regarding mucins is the Mucin Biology Group at the University of Gothenburg in Sweden. There are currently more than 20 human mucin genes that have been identified. The genes encoding mucin proteins are generally designated MUC (MUC1-MUC20) and have homologs in many species other than humans.
Goblet cells produce and secrete mucins which are a component of mucus.
Mucin biology is dynamic and the processes of degradation and turnover are well integrated with biosynthesis to maintain a continuous mucosal protection against all external aggressive forces. Interaction of mucins with microflora plays an important role in normal function.
Se hela listan på frontiersin.org Mucin glycan is the primary determinant of mucin functions. These functions are expanded by three branch structures, including core 2, core 4, and blood group I, which are synthesized by core 2 β1,6 N-acetylglucosaminyltransferase-M (C2GnT-M). Biology Group. 50,714 likes · 151 talking about this. Education The most common O-linked glycans are the mucin-type glycans, which contain an initial GalNAc residue.
These layers work in concert to facilitate the cilia-mediated transport of mucus for the capture and clearance of inhaled materials to prevent lung damage. The mechanisms by which mucin biopolymers protect the lung from injury have been HUGO Gene Nomenclature Committee (HGNC) gene group index page listing all the HGNC gene groups.